Flaviviruses: braking the entering

Flaviviruses

What do Zika, Dengue and West Nile viruses have in common? All are members of a family of viruses called the Flaviviruses. Here, Sonja Best lays out the essentials of this group of significant human pathogens.

Enfuvirtide antiviral activity despite rebound viremia and resistance mutations: fitness tampering or a case of persistent braking on entering?

Combination antiretroviral therapy has revolutionized the care of HIV-1–infected individuals, producing profound improvements in morbidity and mortality. Therapy does not, however, cure HIV infection , and the goal of combination therapy remains the suppression of HIV-1 replication below the limit of detection. Despite a growing array of antiretroviral therapy options, virologic suppression is ...

Evolution of the sequence composition of Flaviviruses.

The adaption of pathogens to their host(s) is a major factor in the emergence of infectious disease and the persistent survival of many of the infectious diseases within the population. Since many of the smaller viral pathogens are entirely dependent upon host machinery, it has been postulated that they are under selection for a composition similar to that of their host. Analyses of sequence co...

Novel flaviviruses from mosquitoes: Mosquito-specific evolutionary lineages within the phylogenetic group of mosquito-borne flaviviruses

Novel flaviviruses that are genetically related to pathogenic mosquito-borne flaviviruses (MBFV) have been isolated from mosquitoes in various geographical locations, including Finland. We isolated and characterized another novel virus of this group from Finnish mosquitoes collected in 2007, designated as Ilomantsi virus (ILOV). Unlike the MBFV that infect both vertebrates and mosquitoes, the M...

Entering the Extranet Era